LS CancerDiag Rebrands to Lynsight

A New Way to Test for Lynch Syndrome

Simplify the path to diagnosis with reliable Lynch syndrome testing. Lynsight’s assay, DiagMMR, tests for mismatch repair deficiency(MMR), giving providers and patients a clear picture about the presence of LS.

Tumor studies & DNA sequencing

Genetic testing has come a long way and is one of the main methods of testing for Lynch syndrome today. Testing typically starts with tumor testing and confirming Lynch syndrome through DNA sequencing. However, this method is limited, introducing challenges for patients, their families, and providers:

Accurate results require knowledge and details of the inherited gene mutation.

Diagnosis requires sophisticated and specialized  interpretations.

53%-60%1-3 Lynch syndrome cases are left undiagnosed.

Testing pathways are often limited to the patient with cancer, instead of testing the entire family.

Get answers, not unclear interpretations
with Lynsight’s test, DiagMMR

Suspected but inconclusive Lynch syndrome cases stress the patient, family, and healthcare system with long and expensive interpretations – and often no answer at all. Lynsight simplifies the path to diagnosis with a reliable test that goes directly to the problem: deficient MMR function.
Here’s how it works.

Time from sample to interpreted results: 4 weeks

Step 01

Sample

In a quick and simple procedure, skin biopsies are collected from the inner forearm and dissected within 4 days for primary cell culture.

Time from sample to interpreted results: 4 weeks

Step 02

Cell Culture

Cells are transferred to a cell culture flask in humid conditions for adherence and growth. After 14 days of initial growth, cells are trypsinized and expanded in a subsequent culture to approximately 1 × 10^8 cells.

Time from sample to interpreted results: 4 weeks

Step 02

Repair

Cells are collected and treated with cold isotonic and hypotonic buffers before disrupting cell membranes. Nuclei are centrifuged, and then the extracted protein sample is desalted.

Time from sample to interpreted results: 4 weeks

Step 02

Algorithm

To distinguish between MMR proficiency and deficiency, the functional MMR efficiency is assessed through a series of reactions and analyses. Repair efficiency is measured as a percentage of repaired DNA of the total amount of DNA in each reaction. 

Time from sample to interpreted results: 4 weeks

Step 02

Result

The test result is quantitative. Interpretations are done based on at least two independent results to ensure accuracy.

Predictive, not reactive

DiagMMR detects MMR deficiency from a minimally invasive, non-malignant tissue sample – before tumors appear.

Functional test

Lynch syndrome testing is done directly on patient cells. Because we extract proteins from patient cells, we don’t need to know the underlying variant. 

Actionable results

While DNA sequencing returns results faster, interpretations can take 6-8 weeks or more. DiagMMR test results are available in 4 weeks and don’t require interpretation – helping patients and families take their next steps faster. 

How to test for Lynch syndrome with DiagMMR

DiagMMR is a clinically test based on over 25 years of research, and Lynsight is working on making DiagMMR accessible across the world. Please get in touch with our team if you have questions or would like to express interest in DiagMMR in your country. 

Next steps after Lynch syndrome testing 

When you get a sure answer about Lynch syndrome, you can get a head start on
prevention strategies and ahead of early signs of cancer. Find your next step today.

Find a path forward

Lynsight offers a new way to test for Lynch syndrome, so healthcare providers can focus on the path instead of the problem. Get in touch today to find out how we can work together.

A New Way to Test for Lynch Syndrome

Simplify the path to diagnosis with reliable Lynch syndrome testing. Lynsight’s assay, DiagMMR, tests for mismatch repair deficiency(MMR), giving providers and patients a clear picture about the presence of LS.

Tumor studies & DNA sequencing

Genetic testing has come a long way and is one of the main methods of testing for Lynch syndrome today. Testing typically starts with tumor testing and confirming Lynch syndrome through DNA sequencing. However, this method is limited, introducing challenges for patients, their families, and providers:

Accurate results require knowledge and details of the inherited gene mutation.

Diagnosis requires sophisticated and specialized  interpretations.

53%-60%1-3 Lynch syndrome cases are left undiagnosed.

Testing pathways are often limited to the patient with cancer, instead of testing the entire family.

Get answers, not unclear interpretations
with Lynsight’s test, DiagMMR

Suspected but inconclusive Lynch syndrome cases stress the patient, family, and healthcare system with long and expensive interpretations – and often no answer at all. Lynsight simplifies the path to diagnosis with a reliable test that goes directly to the problem: deficient MMR function.
Here’s how it works.

Time from sample to interpreted results: 4 weeks

Step 01

Sample

In a quick and simple procedure, skin biopsies are collected from the inner forearm and dissected within 4 days for primary cell culture.

Time from sample to interpreted results: 4 weeks

Step 02

Cell Culture

Cells are transferred to a cell culture flask in humid conditions for adherence and growth. After 14 days of initial growth, cells are trypsinized and expanded in a subsequent culture to approximately 1 × 10^8 cells.

Time from sample to interpreted results: 4 weeks

Step 02

Repair

Cells are collected and treated with cold isotonic and hypotonic buffers before disrupting cell membranes. Nuclei are centrifuged, and then the extracted protein sample is desalted.

Time from sample to interpreted results: 4 weeks

Step 02

Algorithm

To distinguish between MMR proficiency and deficiency, the functional MMR efficiency is assessed through a series of reactions and analyses. Repair efficiency is measured as a percentage of repaired DNA of the total amount of DNA in each reaction. 

Time from sample to interpreted results: 4 weeks

Step 02

Result

The test result is quantitative. Interpretations are done based on at least two independent results to ensure accuracy.

Predictive, not reactive

DiagMMR detects MMR deficiency from a minimally invasive, non-malignant tissue sample – before tumors appear.

Functional test

Lynch syndrome testing is done directly on patient cells. Because we extract proteins from patient cells, we don’t need to know the underlying variant. 

Actionable results

While DNA sequencing returns results faster, interpretations can take 6-8 weeks or more. DiagMMR test results are available in 4 weeks and don’t require interpretation – helping patients and families take their next steps faster. 

How to test for Lynch syndrome with DiagMMR

DiagMMR is a clinically test based on over 25 years of research, and Lynsight is working on making DiagMMR accessible across the world. Please get in touch with our team if you have questions or would like to express interest in DiagMMR in your country. 

Next steps after Lynch syndrome testing 

When you get a sure answer about Lynch syndrome, you can get a head start on
prevention strategies and ahead of early signs of cancer. Find your next step today.

Find a path forward

Lynsight offers a new way to test for Lynch syndrome, so healthcare providers can focus on the path instead of the problem. Get in touch today to find out how we can work together.